Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at University of Illinois Urbana-Champaign previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.…Continue Reading

The BackEnd: Direct debits that “bounce” are a problem, but what’s a fair penalty?

The BackEnd explores the product development process in African tech. We take you into the minds of those who conceived, designed and built the product; highlighting product uniqueness, user behaviour assumptions and challenges during the product cycle. — Yewande issues a standing order for her bank to transfer ₦26,000 (it can vary) to a third…Continue Reading

Klopp has ‘direct line’ with Mbappe; Liverpool ‘ready to fight’

Date published: Wednesday 18th November 2020 10:56 Jurgen Klopp ‘wants to coach’ PSG star Mbappe, with whom he has a ‘direct line’ of communication. Jurgen Klopp ‘wants to coach’ PSG star Kylian Mbappe, with Liverpool ‘ready to fight’ Real Madrid to land the Frenchman. That’s according to Sport (via Sport Witness) who claim the Reds…Continue Reading