Louisville vs. Syracuse odds, line: 2020 college football picks, predictions from model on 39-21 run

Louisville vs. Syracuse odds, line: 2020 college football picks, predictions from model on 39-21 run

After winning their 2020 season opener, the Louisville Cardinals hit the skids, losing their next four contests. They briefly righted the ship with a rout of equally woeful Florida State but have followed with a pair of setbacks. The Cardinals hope to put the brakes on the current slide when they host the ACC-rival Syracuse Orange on Friday. Kickoff from Cardinal Stadium is scheduled for 7 p.m. ET.

Louisville (2-6, 1-6 ACC) suffered its most recent loss on Saturday, a 31-17 defeat at Virginia. The Orange (1-7, 1-6) also are struggling, as their 16-13 setback against Boston College on Nov. 7 was their fifth consecutive loss. The Cardinals are 18.5-point favorites in the latest Louisville vs. Syracuse odds from William Hill Sportsbook, while the over-under for total points scored is 56.5. Before making any Syracuse vs. Louisville picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It is a sizzling 39-21 on top-rated picks through 11 weeks of the 2020 college football season, returning over $1,000 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Syracuse. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Syracuse vs. Louisville:

  • Louisville vs. Syracuse spread: Cardinals -18.5
  • Louisville vs. Syracuse over-under: 56.5 points
  • Louisville vs. Syracuse money line: Cardinals -900, Orange +600
  • LOU: The Cardinals are 5-0 against the spread in their last five games following a contest in which they score fewer than 20 points
  • SYR: The Orange are 1-5 ATS in the last six meetings
Latest Odds:


Why Louisville can cover

Malik Cunningham threw for 161 yards against Virginia to increase his season total to 1,907, putting him 159 away from setting a new career high. The junior quarterback was even more effective versus the Cavaliers with his legs, running for a personal-best 197 yards – the third-highest single-game total by a signal-caller in school history. Cunningham has rushed for 417 yards this year and 1,396 in his career, placing him second on Louisville’s all-time list among quarterbacks.

Cunningham failed to throw a touchdown pass for the first time this season on Saturday but ran for a pair of scores, marking the second time in 2020 he has accomplished that feat. He is just the seventh quarterback in school history to record more than one multi-TD performance on the ground. With leading rusher Javian Hawkins (822 yards, seven TDs) electing to forego the rest of the season and focus on the 2021 NFL Draft, junior Hassan Hall (undisclosed) is expected to be returning just in time.

Why Syracuse can cover

After failing to have success with Tommy DeVito and Rex Culpepper, the Orange gave JaCobian Morgan a chance in their last contest. The freshman completed 19 of his 30 pass attempts against Boston College for 188 yards with one touchdown and one interception. Morgan made his collegiate debut a week earlier versus Wake Forest and was a perfect 7-of-7 for 57 yards and a TD.

Taj Harris is Syracuse’s top receiver as he leads the team in receptions (36), yards (507) and receiving touchdowns (career-high four). The junior, who had a streak of four straight games with a TD catch earlier this season, hauled in seven passes for 61 yards against Boston College. Harris needs five receptions and 58 yards to eclipse the career highs he set during his freshman year.

How to make Louisville vs. Syracuse picks

SportsLine’s model is leaning under on the total. In fact, it says neither team produces a rusher or receiver with 100 or more yards. It also has generated an against-the-spread pick that cashes in almost 70 percent of simulations. You can only get the pick at SportsLine. 

So who wins Syracuse vs. Louisville? And which side of the spread cashes in nearly 70 percent of simulations? Visit SportsLine now to see which side of the Louisville vs. Syracuse spread to jump on, all from the advanced model that is up almost $3,900 on its top-rated college football spread picks, and find out.

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